Publications

Baasch, S., Giansanti, P., Kolter, J., Riedl, A., Forde, A. J., Runge, S., Zenke, S., Elling, R., Halenius, A., Brabletz, S., Hengel, H., Kuster, B., Brabletz, T., Cicin-Sain, L., Arens, R., Vlachos, A., Rohr, J. C., Stemmler, M. P., Kopf, M., Ruzsics, Z., … Henneke, P. (2021). Cytomegalovirus subverts macrophage identity. Cell, 184(14), 3774–3793.e25. https://doi.org/10.1016/j.cell.2021.05.009

Bäuerle, T., Gupta, S., Zheng, S., Seyler, L., Leporati, A., Marosfoi, M., Maschauer, S., Prante, O., Caravan, P., & Bogdanov, A., Jr (2021). Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model. Radiology. Imaging cancer, 3(4), e200069. https://doi.org/10.1148/rycan.2021200069

Bénard A, Mittelstädt A, Klösch B, Glanz K, Müller J, Schoen J, Nüse B, Brunner M, Naschberger E, Stürzl M, Mattner J, Muñoz LE, Sohn K, Grützmann R, Weber GF. IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils. Cell Rep. 2023 Jun 8;42(6):112637. doi: 10.1016/j.celrep.2023.112637

Blazquez, R., Chuang, H. N., Wenske, B., Trigueros, L., Wlochowitz, D., Liguori, R., Ferrazzi, F., Regen, T., Proescholdt, M. A., Rohde, V., Riemenschneider, M. J., Stadelmann, C., Bleckmann, A., Beißbarth, T., van Rossum, D., Hanisch, U. K., & Pukrop, T. (2022). Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain. Oncogene, 41(46), 5008–5019. https://doi.org/10.1038/s41388-022-02496-3

Brabletz, S., Schuhwerk, H., Brabletz, T., & Stemmler, M. P. (2021). Dynamic EMT: a multi-tool for tumor progression. The EMBO journal, 40(18), e108647. https://doi.org/10.15252/embj.2021108647 

Busenhart, P., Montalban-Arques, A., Katkeviciute, E., Morsy, Y., Van Passen, C., Hering, L., Atrott, K., Lang, S., Garzon, J., Naschberger, E., Hartmann, A., Rogler, G., Stürzl, M., Spalinger, M. R., & Scharl, M. (2022). Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer. Journal for immunotherapy of cancer, 10(2), e003465. https://doi.org/10.1136/jitc-2021-003465

Fang Q, Stehr AM, Naschberger E, Knopf J, Herrmann M and Stürzl M (2022) No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment. Front. Immunol. 13:1075260. doi: 10.3389/fimmu.2022.1075260

Fritz, V., Malek, L., Gaza, A., Wormser, L., Appel, M., Kremer, A. E., Thasler, W. E., Siebler, J., Neurath, M. F., Hellerbrand, C., Bosserhoff, A. K., & Dietrich, P. (2021). Combined De-Repression of Chemoresistance Associated Mitogen-Activated Protein Kinase 14 and Activating Transcription Factor 2 by Loss of microRNA-622 in Hepatocellular Carcinoma. Cancers, 13(5), 1183. https://doi.org/10.3390/cancers13051183  

Gaculenko, A., Gregoric, G., Popp, V., Seyler, L., Ringer, M., Kachler, K., Wu, Z., Kisel, W., Hofbauer, C., Hofbauer, L. C., Uder, M., Schett, G., Bäuerle, T., & Bozec, A. (2021). Systemic PPARγ Antagonism Reduces Metastatic Tumor Progression in Adipocyte-Rich Bone in Excess Weight Male Rodents. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(12), 2440–2452. https://doi.org/10.1002/jbmr.4422

Gamez-Belmonte, R., Mahapatro, M., Erkert, L., Gonzalez-Acera, M., Naschberger, E., Yu, Y., Tena-Garitaonaindia, M., Patankar, J. V., Wagner, Y., Podstawa, E., Schödel, L., Bubeck, M., Neurath, M. F., Stürzl, M., & Becker, C. (2022). Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling. Gut, gutjnl-2022-327323. Advance online publication. https://doi.org/10.1136/gutjnl-2022-327323

Gaza, A., Fritz, V., Malek, L., Wormser, L., Treiber, N., Danner, J., Kremer, A. E., Thasler, W. E., Siebler, J., Meister, G., Neurath, M. F., Hellerbrand, C., Bosserhoff, A. K., & Dietrich, P. (2021). Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11. Neoplasia (New York, N.Y.), 23(5), 502–514. https://doi.org/10.1016/j.neo.2021.04.001 

Georg, P., Grasedyck, L., Klever, M., Schill, R., Spang, R., & Wettig, T. (2022). Low-rank tensor methods for Markov chains with applications to tumor progression models. Journal of mathematical biology, 86(1), 7. https://doi.org/10.1007/s00285-022-01846-9

Gregoric, G., Gaculenko, A., Nagel, L., Popp, V., Maschauer, S., Prante, O., Saake, M., Schett, G., Uder, M., Ellmann, S., Bozec, A., & Bäuerle, T. (2022). Non-Invasive Characterization of Experimental Bone Metastasis in Obesity Using Multiparametric MRI and PET/CT. Cancers, 14(10), 2482. https://doi.org/10.3390/cancers14102482

Günther C, Winner B, Neurath MF, Stappenbeck TS. Organoids in gastrointestinal diseases: from experimental models to clinical translation. Gut. 2022 Sep;71(9):1892-1908. doi: 10.1136/gutjnl-2021-326560

Heinen, H., Seyler, L., Popp, V., Hellwig, K., Bozec, A., Uder, M., Ellmann, S., & Bäuerle, T. (2021). Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis. Bone, 144, 115821. https://doi.org/10.1016/j.bone.2020.115821 

Heinlein, Lukas, Benz, Michaela, Kuritcyn, Petr, Bruns, Volker, Hartmann, Arndt, Keil, Felix, Geppert, Carol, Evert, Katja and Wittenberg, Thomas. "Lymph node metastases detection in Whole Slide Images using prototypical patterns and transformer-guided multiple instance learning" Current Directions in Biomedical Engineering, vol. 9, no. 1, 2023, pp. 166-169. https://doi.org/10.1515/cdbme-2023-1042

Hellwig, K., Ellmann, S., Eckstein, M., Wiesmueller, M., Rutzner, S., Semrau, S., Frey, B., Gaipl, U. S., Gostian, A. O., Hartmann, A., Iro, H., Fietkau, R., Uder, M., Hecht, M., & Bäuerle, T. (2021). Predictive Value of Multiparametric MRI for Response to Single-Cycle Induction Chemo-Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma. Frontiers in oncology, 11, 734872. https://doi.org/10.3389/fonc.2021.734872 

Huang J, Demmler R, Mohamed Abdou M, et al. EXPRESS: Rapid qPCR-Based Quantitative Immune Cell Phenotyping in Mouse Tissues. Journal of Investigative Medicine. 2023;0(ja). doi:10.1177/10815589231210497

Huebner, K., Erlenbach-Wuensch, K., Prochazka, J., Sheraj, I., Hampel, C., Mrazkova, B., Michalcikova, T., Tureckova, J., Iatsiuk, V., Weissmann, A., Ferrazzi, F., Kunze, P., Nalli, E., Sammer, E., Gehring, A., Cheema, M. M., Eckstein, M., Paap, E. M., Soederberg, A., Fischer, C., … Schneider-Stock, R. (2022). ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2. Cellular and molecular life sciences : CMLS, 79(8), 423. https://doi.org/10.1007/s00018-022-04445-5

Hübner, J., & Nimmerjahn, F. (2022). Zooming in on dendritic cells for CD40 agonists. Nature cancer, 3(3), 268–269. https://doi.org/10.1038/s43018-022-00340-x

Krug, J., Rodrian, G., Petter, K., Yang, H., Khoziainova, S., Guo, W., Bénard, A., Merkel, S., Gellert, S., Maschauer, S., Spermann, M., Waldner, M., Bailey, P., Pilarsky, C., Liebl, A., Tripal, P., Christoph, J., Naschberger, E., Croner, R., Schellerer, V. S., … Britzen-Laurent, N. (2022). N-glycosylation regulates intrinsic IFN-γ resistance in colorectal cancer: implications for immunotherapy. Gastroenterology, S0016-5085(22)01294-X. Advance online publication. https://doi.org/10.1053/j.gastro.2022.11.018

Lasierra Losada, M., Pauler, M., Vandamme, N., Goossens, S., Berx, G., Leppkes, M., Schuhwerk, H., Brabletz, S., Brabletz, T., & Stemmler, M. P. (2021). Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells. Cell death discovery, 7(1), 138. https://doi.org/10.1038/s41420-021-00522-z 

Leone, M., Cazorla-Vázquez, S., Ferrazzi, F., Wiederstein, J. L., Gründl, M., Weinstock, G., Vergarajauregui, S., Eckstein, M., Krüger, M., Gaubatz, S., & Engel, F. B. (2021). IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability. Molecular cancer research : MCR, 19(10), 1712–1726. https://doi.org/10.1158/1541-7786.MCR-20-0639 

Mass, E., Nimmerjahn, F., Kierdorf, K. et al. Tissue-specific macrophages: how they develop and choreograph tissue biology. Nat Rev Immunol 23, 563–579 (2023). https://doi.org/10.1038/s41577-023-00848-y 

Naschberger E, Flierl C, Huang J, Erkert L, Gamez-Belmonte R, Gonzalez-Acera M, Bober M, Mehnert M, Becker C, Schellerer VS, Britzen-Laurent N and Stürzl M (2023), Analysis of the interferon-γ-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD. Front. Cell Dev. Biol. 11:1213383. doi: 10.3389/fcell.2023.1213383

Naschberger E, Fuchs M, Dickel N, Kunz M, Popp B, Anchang CG, Demmler R, Lyu Y, Uebe S, Ekici AB, Geppert CI, Hartmann A, Flierl C, Petter K, Gass T, Völkl S, Scharl M, Ramming A, Günther C, Merkel S, Schellerer VS, Stürzl M. Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome. Cancer Commun. in press. http://doi.org/10.1002/cac2.12489

Nimmerjahn, F., & Ravetch, J. V. (2021). Four keys to unlock IgG. The Journal of experimental medicine, 218(3), e20201753. https://doi.org/10.1084/jem.20201753

Nimmerjahn, F., Vidarsson, G. & Cragg, M.S. Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy. Nat Immunol 24, 1244–1255 (2023). https://doi.org/10.1038/s41590-023-01544-8

Polisetti, N., Gießl, A., Zenkel, M., Heger, L., Dudziak, D., Naschberger, E., Stich, L., Steinkasserer, A., Kruse, F. E., & Schlötzer-Schrehardt, U. (2021). Melanocytes as emerging key players in niche regulation of limbal epithelial stem cells. The ocular surface, 22, 172–189. https://doi.org/10.1016/j.jtos.2021.08.006

Reitinger, C., Ipsen-Escobedo, A., Hornung, C., Heger, L., Dudziak, D., Lux, A., & Nimmerjahn, F. (2022). Modulation of urelumab glycosylation separates immune stimulatory activity from organ toxicity. Frontiers in immunology, 13, 970290. https://doi.org/10.3389/fimmu.2022.970290

Ruh, M., Stemmler, M. P., Frisch, I., Fuchs, K., van Roey, R., Kleemann, J., Roas, M., Schuhwerk, H., Eccles, R. L., Agaimy, A., Baumhoer, D., Berx, G., Müller, F., Brabletz, T., & Brabletz, S. (2021). The EMT transcription factor ZEB1 blocks osteoblastic differentiation in bone development and osteosarcoma. The Journal of pathology, 254(2), 199–211. https://doi.org/10.1002/path.5659

Saha A, Gavert N, Brabletz T, Ben-Ze'ev A (2022). Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1. Cancers (Basel), 14(18):4478. doi: 10.3390/cancers14184478

Schott, M., Kappelmann-Fenzl, M., Fischer, S., Fernandez-Barrena, M. G., Pineda-Lucena, A., Ávila, M. A., Kuphal, S., & Bosserhoff, A. K. (2022). Impact of CYLD on chromatin structure and histone methylation in malignant melanoma. International journal of molecular medicine, 49(5), 66. https://doi.org/10.3892/ijmm.2022.5122

Schuhwerk, H., Kleemann, J., Gupta, P., van Roey, R., Armstark, I., Kreileder, M., Feldker, N., Ramesh, V., Hajjaj, Y., Fuchs, K., Mahapatro, M., Hribersek, M., Volante, M., Groenewoud, A., Engel, F. B., Ceppi, P., Eckstein, M., Hartmann, A., Müller, F., Kroll, T., … Brabletz, T. (2022). The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response. Cell reports, 41(11), 111819. https://doi.org/10.1016/j.celrep.2022.111819

Seitz, T., Hackl, C., Freese, K., Dietrich, P., Mahli, A., Thasler, R. M., Thasler, W. E., Lang, S. A., Bosserhoff, A. K., & Hellerbrand, C. (2021). Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells. Cancers, 13(3), 511. https://doi.org/10.3390/cancers13030511

Seitz, T., John, N., Sommer, J., Dietrich, P., Thasler, W. E., Hartmann, A., Evert, K., Lang, S. A., Bosserhoff, A., & Hellerbrand, C. (2022). Role of Fibroblast Growth Factors in the Crosstalk of Hepatic Stellate Cells and Uveal Melanoma Cells in the Liver Metastatic Niche. International journal of molecular sciences, 23(19), 11524. https://doi.org/10.3390/ijms231911524

Singh, J., Herrmann, I., Mahajan, A., Schauer, C., Shan, X., Hartmann, A., Rieker, R. J., Evert, K., Falkeis, C., Naschberger, E., von Stillfried, S., Boor, P., Muñoz, L. E., Schett, G., Herrmann, M., & Knopf, J. (2022). A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19. International journal of molecular sciences, 23(23), 15126. https://doi.org/10.3390/ijms232315126

Stehr, A. M., Wang, G., Demmler, R., Stemmler, M. P., Krug, J., Tripal, P., Schmid, B., Geppert, C. I., Hartmann, A., Muñoz, L. E., Schoen, J., Völkl, S., Merkel, S., Becker, C., Schett, G., Grützmann, R., Naschberger, E., Herrmann, M., & Stürzl, M. (2022). Neutrophil extracellular traps drive epithelial-mesenchymal transition of human colon cancer. The Journal of pathology, 256(4), 455–467. https://doi.org/10.1002/path.5860

Stolzer I, Schickedanz L, Chiriac MT, López-Posadas R, Grassl GA, Mattner J, Wirtz S, Winner B, Neurath MF, Günther C. STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8. Mucosal Immunol. 2022 Jan;15(1):130-142. doi: 10.1038/s41385-021-00450-2

Stürzl, M., Kunz, M., Krug, S. M., & Naschberger, E. (2021). Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease. Frontiers in medicine, 8, 643607. https://doi.org/10.3389/fmed.2021.643607

van Roey, R., Brabletz, T., Stemmler, M. P., & Armstark, I. (2021). Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer. Frontiers in cell and developmental biology, 9, 753456. https://doi.org/10.3389/fcell.2021.753456

Vorsatz, C., Friedrich, N., Nimmerjahn, F., & Biburger, M. (2021). There Is Strength in Numbers: Quantitation of Fc Gamma Receptors on Murine Tissue-Resident Macrophages. International journal of molecular sciences, 22(22), 12172. https://doi.org/10.3390/ijms222212172

Wang, H.; Stehr, A.M.; Singh, J.; Zlatar, L.; Hartmann, A.; Evert, K.; Naschberger, E.; von Stillfried, S.; Boor, P.; Muñoz, L.E.; et al. Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA. Int. J. Mol. Sci. 2023, 24, 4101. https://doi.org/ 10.3390/ijms24044101

Werner, A., & Nimmerjahn, F. (2022). HINGEneering IgG for enhanced immune activation. Science immunology, 7(73), eabq4797. https://doi.org/10.1126/sciimmunol.abq4797

Wittner, L.; Wagener, L.; Wiese, J.J.; Stolzer, I.; Krug, S.M.; Naschberger, E.; Jackstadt, R.; Beyaert, R.; Atreya, R.; Kühl, A.A.; et al. Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing. Int. J. Mol. Sci. 2023, 24, 7402. https://doi.org/10.3390/ ijms24087402

Yun, D., Yang, Z., Zhang, S., Yang, H., Liu, D., Grützmann, R., Pilarsky, C., & Britzen-Laurent, N. (2022). An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer. Frontiers in cell and developmental biology, 10, 975684. https://doi.org/10.3389/fcell.2022.975684

Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Feng W, Sun X, Hespe GE, Wang Z, Stemmler MP, Brabletz S, Brabletz T, Keller ET, Ma J, Cho JS, Yang J, Weiss SJ (2023). A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.
The EMBO journal,42(7), e111148. doi: 10.15252/embj.2022111148 

Zundler, S., Günther, C., Kremer, A.E. et al. Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation. Nat Rev Gastroenterol Hepatol 20, 50–64 (2023). https://doi.org/10.1038/s41575-022-00663-1